Análisis de la extracción de péptidos bioactivos obtenidos de colágeno a partir de especies marinas (peces y crustáceos): revisión de literatura

Enrique José Salazar Llorente; María Gabriela Mármol Loyola; Maribel Jessenia Vera Suarez; Fernando Enrique Decker Campuzano

doi:10.59410/RACYT-v11n01ep04-0182

Authors

Enrique José Salazar Llorente Universidad Técnica de Babahoyo https://orcid.org/0000-0002-1699-042X
María Gabriela Mármol Loyola Bureau Veritas (France) https://orcid.org/0009-0006-7168-3680
Maribel Jessenia Vera Suarez Universidad Técnica de Babahoyo https://orcid.org/0000-0002-4058-2370
Fernando Enrique Decker Campuzano Universidad Agraria del Ecuador https://orcid.org/0009-0002-4665-8222

DOI:

https://doi.org/10.59410/RACYT-v11n01ep04-0182

Keywords:

bioactive peptides, enzymatic hydrolysis, ultrasound, antihypertensive

Abstract

The valorization of marine by-products and the development of functional ingredients have driven growing interest in bioactive peptides derived from collagen due to their therapeutic properties and applications in the food industry. This study systematically analyzes the extraction methods, structural characterization, and functional evaluation of these compounds, highlighting their role in the circular bioeconomy. A total of 72 studies published between 2020 and 2025 were reviewed, focusing on antioxidant, antihypertensive, antimicrobial, and osteoprotective activities. Collagen, obtained from structures such as skin, scales, and exoskeletons of marine species, represents a valuable source for generating functional peptides. Among the most studied species are cod, tuna, flounder, shrimp, and crab. Emerging technologies such as ultrasound-assisted extraction, microwave-assisted extraction, and high hydrostatic pressure enable the production of low molecular weight peptides, enhancing their absorption and bioavailability. Various studies have demonstrated that these peptides exhibit high antioxidant capacity, contributing to the neutralization of free radicals, as well as antihypertensive activity through the inhibition of the angiotensin-converting enzyme. Additionally, they show antimicrobial effects against pathogens and potential benefits for bone health. Overall, these properties support their application as functional ingredients in food products, nutraceuticals, and pharmaceuticals.

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